Search results for "free light chain"

showing 3 items of 3 documents

The role of serum free light chain as biomarker of Myasthenia Gravis

2022

Background and aim: Myasthenia gravis (MG) is a B lymphocyte–mediated disease affecting neuromuscular transmission. The clinical course of MG is unpredictable due to the fluctuating nature and heterogeneity of the disease. Increased levels of free light chains (FLC), which reflect B cell activation, have been detected in different autoimmune disorders. In this study, we evaluated the potential role of FLC as diagnostic and prognostic biomarkers of MG. Materials and methods: 74 MG patients and 52 healthy individuals were included in the study. Serum FLC levels were measured by turbidimetric assay (Freelite, The Binding Site Group Ltd) on the Optilite Analyser System in both groups. In MG pat…

Nephelometry and TurbidimetryBiochemistry (medical)Clinical BiochemistryHumansκFLCImmunoglobulin Light ChainsGeneral MedicineBiomarkerBiochemistryMyasthenia gravisBiomarkersAutoantibodiesFree light chains
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The difference of free light chains as a predictor of kidney damage in patients with Multiple Myeloma

2022


 Background: Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal expansion of plasma cells that can release monoclonal immunoglobulins (monoclonal component) or part of theme. Since 2001, the k and λ serum free light chains (sFLC) evaluation and their ratio (rFLC) have made up the laboratory analysis more sensitive and precise in MM patients. The role of rFLC has been widely studied and discussed and now it is validated in the literature. Instead, the value of free light chains difference (dFLC), especially in MM is less known yet. The aim of this study is to evaluate the relationship between the dFLC and the kidney damage parameters in patients with MM, in compa…

lcsh:R5-920medicine.medical_specialtyKidneyCreatinineeducation.field_of_studyProteinuriabusiness.industrylcsh:Public aspects of medicinePopulationUrologyRenal functionlcsh:RA1-1270medicine.diseaseImmunoglobulin light chainMultiple Myeloma free light chains difference free light chains ratio renal damagechemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicineAlbuminuriamedicine.symptomlcsh:Medicine (General)businesseducationMultiple myelomaEpidemiology, Biostatistics, and Public Health
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Clinical Use of κ Free Light Chains Index as a Screening Test for Multiple Sclerosis.

2020

Abstract Objective To assess the usefulness of the κ free light chain index (κFLCi) as a screening test to identify patients with suspected MS. Methods The study included 56 patients with a request to test for oligoclonal bands (OCBs). OCBs were detected by isoelectric focusing, followed by immunofixation. Cerebrospinal fluid (CSF) and serum κFLC were measured by a turbidimetric assay. Also, the κFLC index (κFLCi) was calculated. Results CSF κFLC levels and κFLCi were significantly higher in patients with multiple sclerosis (MS) than in patients with other neurological diseases (NDs; P < .001 and P < .001, respectively). At the cutoff value of 2.9, the κFLCi detected MS with s…

ImmunofixationAdultMale030213 general clinical medicinemedicine.medical_specialtyMultiple SclerosisScreening testClinical BiochemistryκFLCCSFfree light chainImmunoglobulin light chainGastroenterologySensitivity and Specificity03 medical and health sciences0302 clinical medicineCerebrospinal fluidInternal medicinemedicineHumansMass ScreeningAgedOCBbiologybusiness.industryIsoelectric focusingMultiple sclerosisBiochemistry (medical)Middle AgedκFLC indexmedicine.diseaseFree Light Chainmultiple sclerosibiology.proteinbiomarkerBiomarker (medicine)FemaleImmunoglobulin Light Chainsbusiness030217 neurology & neurosurgeryBiomarkersLaboratory medicine
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